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Article

Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age.

Journal of human genetics - 1 Sept 2016

Suzuki Hisato, Fukushima Hiroko, Suzuki Ryoko, Hosaka Sho, Yamaki Yuni, Kobayashi Chie, Sakai Aiko, Imagawa Kazuo, Iwabuchi Atsushi, Yoshimi Ai, Nakao Tomohei, Kato Keisuke, Tsuchida Masahiro, Kiyokawa Nobutaka, Koike Kazutoshi, Noguchi Emiko, Fukushima Takashi, Sumazaki Ryo

Abstract excerpt

The pharmacokinetics among children has been altered dynamically. The difference between children and adults is caused by immaturity in things such as metabolic enzymes and transport proteins. The periods when these alterations happen vary from a few days to some years after birth. We hypothesized that the effect of gene polymorphisms associated with the dose of medicine could be influenced by age. In this study,...

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Source

Identifiers

PMID: 27193222
DOI: 10.1038/jhg.2016.55

Genes

NUDT15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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