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Article

The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia.

Pharmacogenetics and genomics - 1 Jun 2017

Moriyama Takaya, Nishii Rina, Lin Ting-Nien, Kihira Kentaro, Toyoda Hidemi, Jacob Nersting, Kato Motohiro, Koh Katsuyoshi, Inaba Hiroto, Manabe Atsushi, Schmiegelow Kjeld, Yang Jun J, Hori Hiroki

Abstract excerpt

Thiopurines [e.g. mercaptopurine (MP)] are widely used as chemotherapeutic agents in the treatment of pediatric acute lymphoblastic leukemia with dose-limiting hematopoietic toxicity. Recently, germline variants in NUDT15 have been identified as a major genetic cause for MP-related bone marrow suppression, and there is increasing interest in the clinical implementation of NUDT15 genotype-guided MP dose...

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Source

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Identifiers

PMID: 28445187
DOI: 10.1097/FPC.0000000000000282
PMCID: PMC5510236

Genes

NUDT15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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