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Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen <i>Burkholderia thailandensis</i>

2025-03-28

Abstract excerpt

<h4>ABSTRACT</h4> Several human pathogens exploit the kinetic forces generated by polymerizing actin to power their intracellular motility. Human cell-autonomous immune responses activated by the cytokine interferon-gamma (IFNγ) interfere with such microbial actin-based motility, yet the underlying molecular mechanisms are poorly defined. Here, we identify the IFNγ-inducible human giant GTPases GVIN1 as a novel h...

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Identifiers and source

Literature Corpus work
2c816421-1d21-54b2-a3e8-adceeb1c1a74
DOI
10.1101/2025.03.24.645074
Open publication

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Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen <i>Burkholderia thailandensis</i>DOI 10.1101/2025.03.24.645074
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