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Article

Pathogenic microbes manipulate cofilin activity to subvert actin cytoskeleton

8 Apr 2015

Abstract excerpt

Actin-depolymerizing factor (ADF)/cofilin proteins are key players in controlling the temporal and spatial extent of actin dynamics, which is crucial for mediating host-pathogen interactions. Pathogenic microbes have evolved molecular mechanisms to manipulate cofilin activity to subvert the actin cytoskeletal system in host cells, promoting their internalization into the target cells, modifying the replication...

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PMID: 25853495
DOI: 10.3109/1040841x.2015.1010139

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