Article

Cryo-ET of a human GBP coatomer governing cell-autonomous innate immunity to infection

2021-08-27

Abstract excerpt

All living organisms deploy cell-autonomous defenses to combat infection. In plants and animals, these activities generate large supramolecular complexes that recruit immune proteins for protection. Here, we solve the native structure of a massive antimicrobial complex generated by polymerization of 30,000 human guanylate-binding proteins (GBPs) over the entire surface of virulent bacteria. Construction of this gi...

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Identifiers and source

Literature Corpus work: 0e677809-4181-5600-9cfd-48cd1ce90c94
DOI: 10.1101/2021.08.26.457804

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