Article

Detection of cytosolic <i>Shigella flexneri</i> via a C-terminal triple-arginine motif of GBP1 inhibits actin-based motility

2017-11-01

Abstract excerpt

Dynamin-like guanylate binding proteins (GBPs) are gamma interferon (IFNγ)-inducible host defense proteins that can associate with cytosol-invading bacterial pathogens. Mouse GBPs promote the lytic destruction of targeted bacteria in the host cell cytosol but the antimicrobial function of human GBPs and the mechanism by which these proteins associate with cytosolic bacteria are poorly understood. Here, we demonstr...

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Literature Corpus work: f65a54fa-ca7c-587a-97a6-e9a48d249a6a
DOI: 10.1101/212175

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