Article

AI-Based Modeling Reveals APOD⁺ Cancer-Associated Fibroblasts as Key Regulators of Pan-Cancer Therapeutic Response

2026-05-20

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Cancer-associated fibroblast (CAF) heterogeneity plays a pivotal role in treatment failure across diverse malignancies. However, the specific CAF subpopulations driving pan-cancer therapeutic resistance remain incompletely understood. <bold>Methods:</bold> We developed an AI-based modeling framework by integrating single-cell RNA sequencing data from 362,75...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2c64b188-a402-5968-9c7e-fd0c73e343e5
DOI: 10.21203/rs.3.rs-9620045/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AI-Based Modeling Reveals APOD⁺ Cancer-Associated Fibroblasts as Key Regulators of Pan-Cancer Therapeutic ResponseDOI 10.21203/rs.3.rs-9620045/v1Read

Pan-cancer tumor classification by a holistic tumor microenvironment atlasSemantic proximity Read

Determination of permissive and restraining cancer-associated fibroblast (DeCAF) subtypesSemantic proximity Read

Integration of single sample and population analysis for understanding immune evasion mechanisms of lung cancerSemantic proximity Read

A Comprehensive Multi-Omics Analysis Identifies a Robust Scoring System for Cancer-Associated Fibroblasts and Intervention Targets in Colorectal CancerSemantic proximity Read

Exploring the diversity of cancer-associated fibroblasts: insights into mechanisms of drug resistanceSemantic proximity Read

A Multi-Omics Analysis of an Exhausted T Cells’ Molecular Signature in Pan-CancerSemantic proximity Read

Deciphering the Immunomodulatory Function of GSN + Inflammatory Cancer‐Associated Fibroblasts in Renal Cell Carcinoma Immunotherapy: Insights From Pan‐Cancer Single‐Cell Landscape and Spatial Transcriptomics AnalysisSemantic proximity Read

Bulk and single-cell transcriptional profiles reveal roles of fibroblasts and immunocytes in pan-cancer progressionSemantic proximity Read

Cancer‐Associated Fibroblasts: Heterogeneity, Cancer Pathogenesis, and Therapeutic TargetsSemantic proximity Read

Prioritizing exhausted T cell marker genes highlights immune subtypes in pan-cancerSemantic proximity Read

Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironmentSemantic proximity Read

RNA-seq and bulk RNA-seq data analysis of cancer-related fibroblasts (CAF) in LUAD to construct a CAF-based risk signatureSemantic proximity Read