Deciphering the Immunomodulatory Function of GSN + Inflammatory Cancer‐Associated Fibroblasts in Renal Cell Carcinoma Immunotherapy: Insights From Pan‐Cancer Single‐Cell Landscape and Spatial Transcriptomics Analysis

Abstract excerpt

ABSTRACT The heterogeneity of cancer‐associated fibroblasts (CAFs) could affect the response to immune checkpoint inhibitor (ICI) therapy. However, limited studies have investigated the role of inflammatory CAFs (iCAFs) in ICI therapy using pan‐cancer single‐cell RNA sequencing (scRNA‐seq) and spatial transcriptomics sequencing (ST‐seq) analysis. We performed pan‐cancer scRNA‐seq and ST‐seq analyses to identify...

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