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Determination of permissive and restraining cancer-associated fibroblast (DeCAF) subtypes

2024-05-17

Abstract excerpt

Cancer-associated fibroblast (CAF) subpopulations in pancreatic ductal adenocarcinoma (PDAC) have been identified using single-cell RNA sequencing (scRNAseq) with divergent characteristics, but their clinical relevance remains unclear. We translate scRNAseq-derived CAF cell-subpopulation-specific marker genes to bulk RNAseq data, and develop a single- sample classifier, DeCAF, for the classification of clinically...

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Literature Corpus work
8787539a-0309-5cd7-be98-4c087f83ce1b
DOI
10.1101/2024.05.14.594197
Open publication

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Determination of permissive and restraining cancer-associated fibroblast (DeCAF) subtypesDOI 10.1101/2024.05.14.594197
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