Article

Tumour suppressors LKB1 and SMARCA4 functionally interact to regulate gene expression of diverse biological processes in lung cancer

2026-01-28

Abstract excerpt

The tumour suppressor kinase LKB1 is known to regulate the activity of the metabolic sensor AMPK, that when under energy stress shifts metabolism from anabolism to catabolism, thus linking LKB1 to AMPK-mediated gene expression. Coupled with its role as a tumour suppressor kinase, LKB1 is an important metabolic regulator implicated in multiple malignancies and is frequently mutated in lung cancer. Previously, we di...

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Literature Corpus work: 2c07690c-3b60-5834-a60c-6c87d3ea5cc7
DOI: 10.64898/2026.01.26.699134

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