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Article

SMARCA4 alterations in non-small cell lung cancer: a systematic review and meta-analysis.

Journal of clinical pathology - 19 Jun 2024

Wankhede Durgesh, Grover Sandeep, Hofman Paul

Abstract excerpt

AIMS: A mutation in the SMARCA4 gene which encodes BRG1, a common catalytic subunit of switch/sucrose non-fermentable chromatin-remodelling complexes, plays a vital role in carcinogenesis. SMARCA4 mutations are present in approximately 10% of non-small cell lung cancers (NSCLC), making it a crucial gene in NSCLC, but with varying prognostic associations. To explore this, we conducted a systematic review and...

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Identifiers

PMID: 38702192
DOI: 10.1136/jcp-2024-209394

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