SIN-3 coregulator maintains adaptive capacity to different diets in Caenorhabditis elegans through vitamin B12.

Abstract excerpt

Diet has profound effects on metabolism and health, requiring animals to adapt their physiology to varying food sources. Here we show that the conserved SIN3 transcriptional coregulator is required in Caenorhabditis elegans for animals to adapt to different bacterial diets. Shifting sin-3 mutant animals from the commonly used E. coli  OP50 strain to the E. coli  HT115 strain used for RNAi knockdown experiments...

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• Adaptation, Physiological
• Caenorhabditis elegans
• Caenorhabditis elegans Proteins
• Diet
• Escherichia coli