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EGFR-targeted and MMP-activated membranolytic peptides derived from <i>Polybia paulista</i> MP1 kill cancer cells specifically <i>in vitro</i> and reduce tumour growth <i>in vivo</i>

2025-10-07

Abstract excerpt

<h4>ABSTRACT</h4> Membranolytic peptides have demonstrated potential as cancer therapeutics, although targeting to cancer cells and reducing toxicity associated with activity in normal cells remain unmet challenges. We have investigated the membranolytic peptide MP1, from Polybia paulista , in order to assess ways to reduce its non-specific toxicity and thereby improve its characteristics as a cancer therapeutic...

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Literature Corpus work
2be45d19-2d24-5164-942a-aebb204676a6
DOI
10.1101/2025.10.07.680850
Open publication

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EGFR-targeted and MMP-activated membranolytic peptides derived from <i>Polybia paulista</i> MP1 kill cancer cells specifically <i>in vitro</i> and reduce tumour growth <i>in vivo</i>DOI 10.1101/2025.10.07.680850
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