Article

Characterization of TR-107, a Novel Chemical Activator of the Human Mitochondrial Protease ClpP

2022-02-15

Abstract excerpt

We recently described the identification of a new class of small molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the related compound ONC201. In this study, we describe chemical optimization and characterization of the next generation of highly potent and selective small molecule ClpP activators (TR...

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Literature Corpus work: 98cd6d5c-7f9e-51d9-bc9d-a434e575eec3
DOI: 10.1101/2022.02.14.480426

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