Article

Identification of determinants of differential chromatin accessibility through a massively parallel genome-integrated reporter assay

2020-03-03

Abstract excerpt

A key mechanism in cellular regulation is the ability of the transcriptional machinery to physically access DNA. Pioneer transcription factors interact with DNA to open chromatin, which subsequently enables changes to gene expression during development, disease, or as a response to environmental stimuli. However, the regulation of DNA accessibility via the recruitment of transcription factors is difficult to under...

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Literature Corpus work: 2bccd45f-973c-56e1-81a3-75d2609c7f65
DOI: 10.1101/2020.03.02.973396

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