Article
Enhancer architecture and chromatin accessibility constrain phenotypic space during Drosophila development.
Developmental cell - 9 Jan 2023
Galupa Rafael, Alvarez-Canales Gilberto, Borst Noa Ottilie, Fuqua Timothy, Gandara Lautaro, Misunou Natalia, Richter Kerstin, Alves Mariana R P, Karumbi Esther, Perkins Melinda Liu, Kocijan Tin, Rushlow Christine A, Crocker Justin
Abstract excerpt
Developmental enhancers bind transcription factors and dictate patterns of gene expression during development. Their molecular evolution can underlie phenotypical evolution, but the contributions of the evolutionary pathways involved remain little understood. Here, using mutation libraries in Drosophila melanogaster embryos, we observed that most point mutations in developmental enhancers led to changes in gene...
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