Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance

doi:10.1038/s41419-020-03144-y

Article

Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance

2 Nov 2020

Abstract excerpt

Defects in apoptosis can promote tumorigenesis and impair responses of malignant B cells to chemotherapeutics. Members of the B-cell leukemia/lymphoma-2 (BCL-2) family of proteins are key regulators of the intrinsic, mitochondrial apoptotic pathway. Overexpression of antiapoptotic BCL-2 family proteins is associated with treatment resistance and poor prognosis. Thus, inhibition of BCL-2 family proteins is a...

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