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The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy

20 Mar 2025

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Abstract The B cell lymphoma 2 (BCL2) protein family critically controls apoptosis by regulating the release of cytochrome c from mitochondria. In this cutting-edge review, we summarize the basic biology regulating the BCL2 family including canonical and non-canonical functions, and highlight milestones from basic research to clinical applications in cancer and other pathophysiological conditions. We review...

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CAR-T cell therapy research
Protein Degradation and Inhibitors
Ubiquitin and proteasome pathways

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40113751
DOI: 10.1038/s41392-025-02176-0

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