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Targeting Mitochondrial Apoptosis to Overcome Treatment Resistance in Cancer

2 Mar 2020

Abstract excerpt

Deregulated cellular apoptosis is a hallmark of cancer and chemotherapy resistance. The B-cell lymphoma 2 (BCL-2) protein family members are sentinel molecules that regulate the mitochondrial apoptosis machinery and arbitrate cell fate through a delicate balance between pro- and anti-apoptotic factors. The recognition of the anti-apoptotic BCL2 gene as an oncogenic driver in hematological malignancies has...

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PMID: 32131385
DOI: 10.3390/cancers12030574

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