Article
Targeting anti‐apoptotic BCL 2 family proteins in haematological malignancies – from pathogenesis to treatment
27 Apr 2017
Abstract excerpt
Summary The B‐cell lymphoma 2 (BCL2) family of proteins comprise key regulators of apoptosis and are implicated in the pathogenesis of many malignancies, including lymphomas and leukaemias. Targeting of BCL2 proteins can be directly toxic to tumour cells or render them more sensitive to chemotherapy. Inhibition of the anti‐apoptotic functions of BCL2 proteins using structure‐based design to produce specific...
Topics
Join the communities discussing this publication.