Article
WSB1 promotes tumor metastasis by inducing pVHL degradation.
Genes & development - 1 Nov 2015
Kim Jung Jin, Lee Seung Baek, Jang Jinsung, Yi Sang-Yeop, Kim Sun-Hyun, Han Sang-Ah, Lee Jong-Min, Tong Seo-Yun, Vincelette Nicole D, Gao Bowen, Yin Ping, Evans Debra, Choi Dong Wook, Qin Bo, Liu Tongzheng, Zhang Haoxing, Deng Min, Jen Jin, Zhang Jun, Wang Liewei, Lou Zhenkun
Abstract excerpt
The von Hippel-Lindau tumor suppressor pVHL is an E3 ligase that targets hypoxia-inducible factors (HIFs). Mutation of VHL results in HIF up-regulation and contributes to processes related to tumor progression such as invasion, metastasis, and angiogenesis. However, very little is known with regard to post-transcriptional regulation of pVHL. Here we show that WD repeat and SOCS box-containing protein 1 (WSB1) is...
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