Article

Transcriptome sequencing revealed differences in the response of renal cancer cells to hypoxia and CoCl2 treatment

2015-12-30

Abstract excerpt

Human cancer cells are subjected to hypoxic conditions in many tumours. Hypoxia causes alterations in the glycolytic pathway activation through stabilization of hypoxia-inducible factor 1. Currently, two approaches are commonly used to model hypoxia: an alternative to generating low-oxygen conditions in an incubator, cells can be treated with CoCl 2 . We performed RNA-seq experiments to study transcriptomes of hu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2b992800-3a18-5680-a2a2-eb438e8ef033
DOI: 10.12688/f1000research.7571.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptome sequencing revealed differences in the response of renal cancer cells to hypoxia and CoCl2 treatmentDOI 10.12688/f1000research.7571.1Read

Transcriptomic changes in human renal proximal tubular cells revealed under hypoxic conditions by RNA sequencing.Semantic proximity Read

Systematic Analysis of Transcriptomic Profile of Renal Cell Carcinoma under Long-Term Hypoxia Using Next-Generation Sequencing and BioinformaticsSemantic proximity Read

Identification of a novel papillary renal cell carcinoma molecular subtype characterized by HIF-pathway over-activationSemantic proximity Read

Proteomic analysis of signaling network regulation in renal cell carcinomas with differential hypoxia-inducible factor-2α expression.Semantic proximity Read

Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinomaSemantic proximity Read

Hypoxia-inducible factors drive miRNA-mediated downregulation of <i>L2HGDH</i> and <i>HIF1A</i> in clear cell renal cancer independent of 14q deletionSemantic proximity Read

Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcriptsSemantic proximity Read

Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygenSemantic proximity Read

Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cellsSemantic proximity Read

The hypoxia-mimetic agent cobalt chloride induces cell cycle arrest and alters gene expression in U266 multiple myeloma cellsSemantic proximity Read

Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T CellsSemantic proximity Read

Identification of transcriptome-wide cobalt chloride-induced hypoxia-responsive long noncoding RNAs regulated by cytoplasmic mRNA capping enzymeSemantic proximity Read