Article

Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma

2024-01-20

Abstract excerpt

<h4>SUMMARY</h4> Copper (Cu) is an essential trace element required for mitochondrial respiration. Late-stage clear cell renal cell carcinoma (ccRCC) accumulates Cu and allocates it to mitochondrial cytochrome c oxidase. We show that Cu drives coordinated metabolic remodeling of bioenergy, biosynthesis and redox homeostasis, promoting tumor growth and progression of ccRCC. Specifically, Cu induces TCA cycle-depen...

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Literature Corpus work: 05c2c58a-5854-55f8-bf07-7a8f68b6598b
DOI: 10.1101/2024.01.16.575895

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