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Article

Proteomic analysis of signaling network regulation in renal cell carcinomas with differential hypoxia-inducible factor-2α expression.

PloS one - 1 Jan 2013

Nagaprashantha Lokesh Dalasanur, Talamantes Tatjana, Singhal Jyotsana, Guo Jia, Vatsyayan Rit, Rauniyar Navin, Awasthi Sanjay, Singhal Sharad S, Prokai Laszlo

Abstract excerpt

BACKGROUND: The loss of von Hippel-Lindau (VHL) protein function leads to highly vascular renal tumors characterized by an aggressive course of disease and refractoriness to chemotherapy and radiotherapy. Loss of VHL in renal tumors also differs from tumors of other organs in that the oncogenic cascade is mediated by an increase in the levels of hypoxia-inducible factor-2α (HIF2α) instead of hypoxia-inducible...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Kidney Neoplasms

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Source

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Identifiers

PMID: 23940778
DOI: 10.1371/journal.pone.0071654
PMCID: PMC3733962

Genes

VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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