Article

Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen

2018-09-26

Abstract excerpt

<h4>Background: </h4> Little is known about the impact of nutrients on cellular transcriptional responses, especially in face of environmental stressors such as oxygen deprivation. Hypoxia-inducible factors (HIF) coordinate the expression of genes essential for adaptation to oxygen-deprived environments. A second family of oxygen-sensing genes known as the alpha-ketoglutarate-dependent dioxygenases are also implic...

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Literature Corpus work: cc853dd4-63bb-5e89-9da0-8df9aaaf4ea8
DOI: 10.12688/wellcomeopenres.14839.1

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