Acidity-Responsive Therapeutic Gene Circuits for Tumor Microenvironment Reprogramming: A Computational Design Framework

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : Tumor microenvironments (TMEs) are characterized by pathological acidity (pH ~6.5) that suppresses immune function, promotes metastasis, and reduces therapeutic efficacy. Synthetic gene circuits offer programmable responses to TME acidity, but rational design has been hindered by the lack of integrated computational frameworks that couple circuit dynamics wi...

Topics

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• Acidosis
• Biological Evolution
• Homeostasis
• Hydrogen-Ion Concentration
• Models, Biological
• Neoplasms
• Phenotype
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

2b920633-150a-566b-b91a-34dec53f525c

DOI

10.21203/rs.3.rs-8321363/v1