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Changes to culture pH and dissolved oxygen can enhance chimeric antigen receptor T‐cell generation and differentiation

14 May 2022

Abstract excerpt

Chimeric antigen receptor (CAR) T-cell therapy is growing clinically and commercially as a powerful new approach to treat cancer. Understanding how key culture conditions such as pH and dissolved oxygen (DO) affect CAR T-cell generation and function is important in developing better CAR-T manufacturing processes and CAR T-cell therapies for patients. We used the automated mini-bioreactor (AMBR) 15 platform to...

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PMID: 35567431
DOI: 10.1002/btpr.3275

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