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Evolutionary dynamics of acid resistance in tumors: A mathematical model.

Mathematical biosciences and engineering : MBE - 27 Jan 2026

Anickode Prithvi, Milner Fabio Augusto

Abstract excerpt

Acidosis in tumors arises from reprogrammed metabolism and compromised vasculature, creating a harsh, acidic microenvironment that drives the evolutionary selection of acid-resistant cell phenotypes. A mathematical model was proposed to integrate phenotypic evolution, microenvironmental acidification, and tumor density dynamics. Three key mechanisms were incorporated in it: frequency-dependent selection favoring...

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Acidosis
Biological Evolution
Computer Simulation
Hydrogen-Ion Concentration
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Microenvironment

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PMID: 41786593
DOI: 10.3934/mbe.2026023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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