Article

A microfluidic model to recapitulate pH and oxygen gradients in solid tumors

2025-07-09

Abstract excerpt

The tumor microenvironment (TME) plays critical roles in cancer development, aggressiveness, and treatment resistance. The TME comprises cellular (stromal) components as well as gradients of physicochemical properties, including hypoxia and acidosis. Understanding of how hypoxia and acidosis gradients impact cancer phenotypes is lacking, in large part due to challenges in precisely mimicking and controlling such g...

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Literature Corpus work: 7c12cb66-4802-5287-8c21-4dd96e1e60c0
DOI: 10.1101/2025.07.05.663284

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