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Programmable Bivalent Peptide–DNA Locks for pH-Based Control of Antibody Activity

23 Dec 2019

Abstract excerpt

The ability to control antibody activity by pH has important applications in diagnostics, therapeutic antibody targeting, and antibody-guided imaging. Here, we report the rational design of bivalent peptide-DNA ligands that allow pH-dependent control of antibody activity. Our strategy uses a pH-responsive DNA triple helix to control switching from a tight-binding bivalent peptide-DNA lock into a weaker-binding...

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Share to Advanced biosensing and bioanalysis techniques
Share to Monoclonal and Polyclonal Antibodies Research
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PMID: 31989023
DOI: 10.1021/acscentsci.9b00964

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