Article

A single <i>de novo</i> substitution in SARS-CoV-2 spike informs enhanced adherence to human ACE2

2021-07-16

Abstract excerpt

SARS-CoV-2 initiates colonization of host cells by binding to cell membrane ACE2 receptor. This binding is mediated by the viral spike receptor binding domain (RBD). The COVID-19 pandemic has brought devastating consequences at a clinical, social and economical levels. Therefore, anticipation of potential novel SARS-causing species or SARS-CoV-2 variants with enhanced binding to ACE2 is key in the prevention of fu...

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Literature Corpus work: 2b68d62e-9398-5971-abd9-a2686e9d6930
DOI: 10.1101/2021.07.16.452441

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