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Development of a recombinant adeno-associated virus vector for human T lymphocyte- and natural killer cell-targeted gene therapy

2026-02-27

Abstract excerpt

Recombinant adeno-associated virus (rAAV) vectors are widely used for gene delivery but show limited efficiency in immune cells, including T lymphocytes and natural killer (NK) cells. To overcome this barrier, we developed a modular rAAV vector engineering strategy that integrates capsid retargeting with genome optimization. We report a CD7-targeted rAAV vector (CD7-AAV6/9) featuring a nanobody-fused hybrid capsid...

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Identifiers and source

Literature Corpus work
2b5ea77e-0ee2-544c-89a0-ea48b8025516
DOI
10.64898/2026.02.26.707014
Open publication

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Development of a recombinant adeno-associated virus vector for human T lymphocyte- and natural killer cell-targeted gene therapyDOI 10.64898/2026.02.26.707014
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