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Non-viral approaches in CAR-NK cell engineering: connecting natural killer cell biology and gene delivery

10 Sept 2024

Abstract excerpt

Abstract Natural Killer (NK) cells are exciting candidates for cancer immunotherapy with potent innate cytotoxicity and distinct advantages over T cells for Chimeric Antigen Receptor (CAR) therapy. Concerns regarding the safety, cost, and scalability of viral vectors has ignited research into non-viral alternatives for gene delivery. This review comprehensively analyses recent advancements and challenges with...

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PMID: 39256765
DOI: 10.1186/s12951-024-02746-4

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