Article

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis

2020-06-06

Abstract excerpt

<h4>Background</h4> High throughput single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for exploring cellular heterogeneity amongst complex human cancers. scRNA-Seq studies using fresh human surgical tissue is logistically difficult, precludes histopathological triage of samples and limits the ability to perform batch processing. This hinderance can often introduce technical biases when integra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2b52b327-a030-587a-a944-a475eac38657
DOI: 10.1101/2020.06.04.135277

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysisDOI 10.1101/2020.06.04.135277Read

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysisSemantic proximity Read

A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumorsSemantic proximity Read

Evaluation of single-cell RNA profiling technologies using FFPE, fresh, and frozen ccRCC tumor specimensSemantic proximity Read

scONE-seq: A one-tube single-cell multi-omics method enables simultaneous dissection of molecular phenotype and genotype heterogeneity from frozen tumorsSemantic proximity Read

A single-cell and single-nucleus RNA-seq toolbox for fresh and frozen human tumorsSemantic proximity Read

Single-Cell Transcriptomics Sheds Light on Tumor Evolution: Perspectives from City of Hope’s Clinical Trial TeamsSemantic proximity Read

Single‐cell RNA sequencing to explore cancer‐associated fibroblasts heterogeneity: “Single” vision for “heterogeneous” environmentSemantic proximity Read

Routine FFPE sections support clinically compatible single-nucleus transcriptomics across six human cancer typesSemantic proximity Read

Single-cell RNA-seq variant analysis for exploration of genetic heterogeneity in cancerSemantic proximity Read

scONE-seq: A single-cell multi-omics method enables simultaneous dissection of phenotype and genotype heterogeneity from frozen tumors.Semantic proximity Read

Single‐cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasisSemantic proximity Read

A Pan-cancer Blueprint of the Heterogeneous Tumour Microenvironment Revealed by Single-Cell ProfilingSemantic proximity Read