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Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis

10 May 2021

Abstract excerpt

BACKGROUND: High throughput single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for exploring cellular heterogeneity among complex human cancers. scRNA-Seq studies using fresh human surgical tissue are logistically difficult, preclude histopathological triage of samples, and limit the ability to perform batch processing. This hindrance can often introduce technical biases when integrating...

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PMID: 33971952
DOI: 10.1186/s13073-021-00885-z

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