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Article

HAMLET interacts with lipid membranes and perturbs their structure and integrity.

PloS one - 23 Feb 2010

Mossberg Ann-Kristin, Puchades Maja, Halskau Øyvind, Baumann Anne, Lanekoff Ingela, Chao Yinxia, Martinez Aurora, Svanborg Catharina, Karlsson Roger

Abstract excerpt

BACKGROUND: Cell membrane interactions rely on lipid bilayer constituents and molecules inserted within the membrane, including specific receptors. HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a tumoricidal complex of partially unfolded alpha-lactalbumin (HLA) and oleic acid that is internalized by tumor cells, suggesting that interactions with the phospholipid bilayer and/or specific receptors...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20186341
DOI: 10.1371/journal.pone.0009384
PMCID: PMC2826418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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