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Article

Atrial Natriuretic Peptide　- Old But New Therapeutic in Cardiovascular Diseases.

Circulation journal : official journal of the Japanese Circulation Society - 23 Jun 2017

Ichiki Tomoko, Burnett John C

Abstract excerpt

With the discovery of atrial natriuretic peptide (ANP), the heart as an endocrine organ was established. Basic science revealed that ANP, through the particulate guanylyl cyclase A receptor and cGMP, plays a fundamental role in cardiorenal biology. This work has led to the development of ANP as a therapeutic, especially in heart failure (HF). Human genomics has strengthened our understanding of ANP, revealing...

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PMID: 28552863
DOI: 10.1253/circj.CJ-17-0499

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