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Article

Identification of Gene Expression Signatures for Phenotype-Specific Drug Targeting of Cardiac Fibrosis.

International journal of molecular sciences - 18 Apr 2023

Lukovic Dominika, Hasimbegovic Ena, Winkler Johannes, Mester-Tonczar Julia, Müller-Zlabinger Katrin, Han Emilie, Spannbauer Andreas, Traxler-Weidenauer Denise, Bergler-Klein Jutta, Pavo Noemi, Goliasch Georg, Batkai Sandor, Thum Thomas, Zannad Faiez, Gyöngyösi Mariann

Abstract excerpt

We have designed translational animal models to investigate cardiac profibrotic gene signatures. Domestic pigs were treated with cardiotoxic drugs (doxorubicin, DOX, n = 5 or Myocet®, MYO, n = 5) to induce replacement fibrosis via cardiotoxicity. Reactive interstitial fibrosis was triggered by LV pressure overload by artificial isthmus stenosis with stepwise developing myocardial hypertrophy and final fibrosis...

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Source

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Identifiers

PMID: 37108624
DOI: 10.3390/ijms24087461
PMCID: PMC10139067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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