Article

Cardiomyocytes Deficiency of SENP1 Promotes Myocardial Fibrosis via Paracrine Action

2023-06-24

Abstract excerpt

<h4>Background</h4> SENP1 (Sentrin-specific protease 1) is involved in heart disease by regulating intracellular SUMOylation. However, the role of cell type-specific SENP1 in the setting of myocardial infarction (MI) remains to be defined. We determined whether cardiomyocyte-specific SENP1 regulates maladaptive remodeling in the ischemic heart. <h4>Methods</h4> We generated cardiomyocyte-specific SENP1 knockout...

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Literature Corpus work: dad899a7-37a1-52d7-bbf1-095a698e3bcb
DOI: 10.1101/2023.06.21.546019

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