Article

Neprilysin mediated cleavage of phospholamban dysregulates SERCA in heart failure

2026-06-29

Abstract excerpt

<h4>Background</h4> Neprilysin (NEP) is a zinc-dependent metalloprotease targeted in heart failure therapy to prevent it degrading circulating cardioprotective vasoactive peptides. NEP can also cleave sarcolipin (SLN), the skeletal- and atrial muscle-specific micropeptide regulator of the sarcoplasmic reticulum Ca 2+ -ATPase (SERCA). A direct pathophysiological role of NEP in ventricular muscle has not been esta...

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Literature Corpus work: 0fef3ca2-5d8e-5b5e-b0fa-a5a313bf7f23
DOI: 10.64898/2026.06.23.732949

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