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SF3B4 Drives Alternative 5′ Splice Site Selection of HOXA11-AS to Promote Metabolic Reprogramming and Reduced Cisplatin Sensitivity in ESCC

2026-08-12

Abstract excerpt

<title>Abstract</title> <p>Reduced cisplatin sensitivity limits treatment responses in esophageal squamous cell carcinoma (ESCC), yet the isoform-level RNA-processing mechanisms that connect metabolic adaptation to treatment response remain poorly defined. Here, integrative analyses of public datasets and clinical cohorts identified splicing factor 3b subunit 4 (SF3B4) as an ESCC-upregulated splicing regulator an...

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Literature Corpus work: 2b2560e9-bea1-5eae-a08c-9d2e8d93f458
DOI: 10.21203/rs.3.rs-3086784/v2

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