Article

The SF3B1R625H Mutation Promotes Prolactinoma Tumor Progression Through Aberrant Splicing Of DLG1

2021-09-28

Abstract excerpt

<h4>Background: </h4> Recently, a hotspot mutation in prolactinoma was observed in splicing factor 3b subunit 1 ( SF3B1 R625H ), but its functional effects and mechanisms are poorly understood. Methods Using the CRISPR/Cas9 genome editing system and rat pituitary GH3 cells, we generated heterozygous Sf3b1 R625H mutant cells. Sanger and whole-genome sequencing were conducted to verify the introduction of this muta...

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Literature Corpus work: 4b474b2b-d2a7-5394-ae72-954d9272fa26
DOI: 10.21203/rs.3.rs-934219/v1

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