Article

SF3B4 Drives Alternative 5′ Splice Site Selection of HOXA11-AS to Promote Metabolic Reprogramming and Reduced Cisplatin Sensitivity in ESCC

2026-08-12

Abstract excerpt

<title>Abstract</title> <p>Reduced cisplatin sensitivity limits treatment responses in esophageal squamous cell carcinoma (ESCC), yet the isoform-level RNA-processing mechanisms that connect metabolic adaptation to treatment response remain poorly defined. Here, integrative analyses of public datasets and clinical cohorts identified splicing factor 3b subunit 4 (SF3B4) as an ESCC-upregulated splicing regulator an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 21517aae-a294-503e-bcbf-e4354bbc6e71
DOI: 10.21203/rs.3.rs-10663843/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SF3B4 Drives Alternative 5′ Splice Site Selection of HOXA11-AS to Promote Metabolic Reprogramming and Reduced Cisplatin Sensitivity in ESCCDOI 10.21203/rs.3.rs-10663843/v1Read

SF3B4 Drives Alternative 5′ Splice Site Selection of HOXA11-AS to Promote Metabolic Reprogramming and Reduced Cisplatin Sensitivity in ESCCSemantic proximity Read

SF3B4 Regulated Alternative Splicing that Produced an Oncogenic Isoform of HOXA11-AS to Promote Glycolytic Reprogramming and ESCC ProgressionSemantic proximity Read

The RNA-binding protein La/SSB drives head and neck squamous cell carcinoma progression through TFAP2C-mediated transcriptional activation of FSCN1Semantic proximity Read

SF3B4 Plays an Oncogenic Role in Esophageal Squamous Cell CarcinomaSemantic proximity Read

Hypoxia-inducible factor 1-alpha and lactate dehydrogenase-A axis in metabolic changes and aggression in esophageal squamous-cell carcinomaSemantic proximity Read

SMARCA4 regulates spatially restricted metabolic plasticity in 3D multicellular tissueSemantic proximity Read

SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A-c-Myc axis.Semantic proximity Read

FOXA1/2 depletion drives global reprogramming of differentiation state and metabolism in a human liver cell line and inhibits differentiation of human stem cell-derived hepatic progenitor cellsSemantic proximity Read

Hexokinase 1b is a novel target for Non–small-cell lung cancerSemantic proximity Read

Epigenetic coordination of transcriptional and translational programs in hypoxiaSemantic proximity Read

The SF3B1R625H Mutation Promotes Prolactinoma Tumor Progression Through Aberrant Splicing Of DLG1Semantic proximity Read

SINHCAF/FAM60A links SIN3A function to the hypoxia response and its levels are predictive of cancer patient survivalSemantic proximity Read