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Hypoxia-inducible factor 1-alpha and lactate dehydrogenase-A axis in metabolic changes and aggression in esophageal squamous-cell carcinoma

13 Feb 2025

Abstract excerpt

BACKGROUND Esophageal squamous-cell carcinoma (ESCC) is a highly aggressive cancer, predominantly affecting populations in Eastern Asia and parts of Africa. Its pathogenesis is influenced by both genetic and environmental factors. Despite recent therapeutic advances, survival rates remain dismal, underscoring an urgent need for novel therapeutic targets. AIM To investigate the role of hypoxia-inducible factor...

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Share to Adrenal and Paraganglionic Tumors
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PMID: 40092940
DOI: 10.4251/wjgo.v17.i3.103450

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