Article

SigFormer: an Attention-Based Framework for Robust Single-Sample Mutational Signature Decomposition

2026-01-21

Abstract excerpt

Somatic mutational signatures imprint the history of exogenous exposures and endogenous processes on the genome, offering critical insights into pathologic etiology and disease risk. However, accurate signature decomposition at the single-sample level is still challenging when mutation burden is low, sampling noise is high, and candidate catalogs are large and redundant. Here, we present SigFormer, a set-condition...

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Literature Corpus work: 2b1b2ac3-4af5-5fa0-bc8e-8fafa33795f3
DOI: 10.64898/2026.01.20.700228

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