Article

Structure-guided optimization of light-activated chimeric G-protein coupled receptors

2021-12-14

Abstract excerpt

<h4>ABSTRACT</h4> G-protein coupled receptors (GPCRs) are the largest human receptor family and involved in virtually every physiological process. One hallmark of GPCR function is the specific coupling of activated receptors to selected downstream signaling pathways. The ability to tune this coupling would permit the development of receptors with new capabilities. GPCRs and G-proteins have been recently resolved...

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Literature Corpus work: 2b1af247-739d-55e1-9b24-4f922ff2505f
DOI: 10.1101/2021.12.13.472518

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