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Article

G Protein-Coupled Receptors Contain Two Conserved Packing Clusters.

Biophysical journal - 6 Jun 2017

Sanchez-Reyes Omar B, Cooke Aidan L G, Tranter Dale B, Rashid Dawood, Eilers Markus, Reeves Philip J, Smith Steven O

Abstract excerpt

G protein-coupled receptors (GPCRs) have evolved a seven-transmembrane helix framework that is responsive to a wide range of extracellular signals. An analysis of the interior packing of family A GPCR crystal structures reveals two clusters of highly packed residues that facilitate tight transmembrane helix association. These clusters are centered on amino acid positions 2.47 and 4.53, which are highly conserved...

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Identifiers

PMID: 28591604
DOI: 10.1016/j.bpj.2017.04.051
PMCID: PMC5474883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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