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Article

Gi- and Gs-coupled GPCRs show different modes of G-protein binding.

Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2018

Van Eps Ned, Altenbach Christian, Caro Lydia N, Latorraca Naomi R, Hollingsworth Scott A, Dror Ron O, Ernst Oliver P, Hubbell Wayne L

Abstract excerpt

More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered. Upon light-induced changes in ligand-receptor interaction, movement of specific transmembrane helices within the receptor opens a crevice at the cytoplasmic surface, allowing for coupling of heterotrimeric guanine nucleotide-binding proteins (G...

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Identifiers

PMID: 29463720
DOI: 10.1073/pnas.1721896115
PMCID: PMC5877964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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