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Article

Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis.

The Journal of biological chemistry - 18 Jan 2008

Ye Shixin, Köhrer Caroline, Huber Thomas, Kazmi Manija, Sachdev Pallavi, Yan Elsa C Y, Bhagat Aditi, RajBhandary Uttam L, Sakmar Thomas P

Abstract excerpt

G protein-coupled receptors (GPCRs) are ubiquitous heptahelical transmembrane proteins involved in a wide variety of signaling pathways. The work described here on application of unnatural amino acid mutagenesis to two GPCRs, the chemokine receptor CCR5 (a major co-receptor for the human immunodeficiency virus) and rhodopsin (the visual photoreceptor), adds a new dimension to studies of GPCRs. We incorporated the...

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Identifiers

PMID: 17993461
DOI: 10.1074/jbc.M707355200

Genes

CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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