Article

Cadherin-13 is a critical regulator of GABAergic modulation in human stem cell derived neuronal networks

2020-05-07

Abstract excerpt

<h4>Summary</h4> Activity in the healthy brain relies on concerted interplay of excitation (E) and inhibition (I) via balanced synaptic communication between glutamatergic and GABAergic neurons. A growing number of studies imply that disruption of this E/I balance is a commonality in many brain disorders, however, obtaining mechanistic insight into these disruptions, with translational value for the human patient...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2aeaca85-0a85-5ea7-baa5-5b357c89dfb3
DOI: 10.1101/2020.05.07.082453

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cadherin-13 is a critical regulator of GABAergic modulation in human stem cell derived neuronal networksDOI 10.1101/2020.05.07.082453Read

Expanding GABAergic Neuronal Diversity in PSC-Derived Disease ModelsSemantic proximity Read

Human stem cell-derived GABAergic interneuron development reveals early emergence of subtype diversity followed by gradual electrochemical maturationSemantic proximity Read

<i>ST3GAL3</i> loss-of-function disrupts synaptic integrity and excitatory/inhibitory cortical dynamicsSemantic proximity Read

hiPSC-derived cortical neurons from ADHD individuals reveal dysregulated glutamatergic developmentSemantic proximity Read

Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.Semantic proximity Read

Human Medial Ganglionic Eminence Organoids Robustly Generate Parvalbumin Interneurons and Fast-Spiking Neurons and Reveal Migratory Deficits in SLC6A1 Deficient InterneuronsSemantic proximity Read

<i>APOE4</i> impacts cortical neurodevelopment and alters network formation in human brain organoidsSemantic proximity Read

Rapid and reproducible <i>in vitro</i> generation of human parvalbumin-expressing cortical interneuronsSemantic proximity Read

APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoidsSemantic proximity Read

L-type voltage-gated calcium channel regulation of <i>in vitro</i> human cortical neuronal networksSemantic proximity Read

Impact of the ADHD-susceptibility gene CDH13 on development and function of brain networks.Semantic proximity Read

Expression profile of the ADHD risk gene <i>ADGRL3</i> during human neurodevelopment and the effects of genetic variationSemantic proximity Read